ENDOKRYNOLOGIA PEDIATRYCZNA PDF

Karola Marcinkowskiego w Poznaniu Adres do korespondencji: dr hab. Ghrelin is a 28 aminoacid peptide that stimulates the release of the growth hormone. Discovered at the turn of the centuriesand pursued for many years, it turned out to be a natural receptor ligand for substances releasing the growth hormone. Serine octynylation in the 3 position gives ghrelin unique properties traversing the brain-blood barrier, which constitutes a unique value to peptides. It might warrant a totally new approach to contemporary model of the liberin-statin-hormone hormonal activity. Ghrelin seems to be involved in the majority of life functions of the organism.

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We wszystkich przypadkach w ocenie histopatologicznej stwierdzono cechy charakterystyczne dla pheochromocytoma. Three cases of childhood adrenocortical tumours are presented to compare clinical and histopathological diagnosis.

Virilizing adrenocortical tumours were clinically diagnosed in two patients, the third case was an unusual in children incidentaloma. Histopathological signs of pheochromocytoma were present in all adrenocortical tumours. Difficulties in diagnosis in the presented cases suggest the necessity of performing widespread hormonal investigations before the start of treatment. Przypadek 1 A.

Przez pierwszy rok po zabiegu operacyjnym stosowano leczenie substytucyjne hydrokortyzonem. W czasie 2,5-letniej obserwacji nie stwierdzono nawrotu choroby. Po 2 latach u dziewczynki wykonano zabieg plastyki krocza, z dobrym efektem kosmetycznym. Przypadek 2 Z. Matka dziewczynki jest nosicielem mutacji genu p53 w wywiadzie guz piersi i torbiel jajnika.

Wiek kostny oceniono na dwa lata, co oznacza przyspieszenie o 1 rok w stosunku do wieku kalendarzowego. Tabela I. Results of hormonal studies in a patient A. Histopato57 Praca kazuistyczna Endokrynol. Results of hormonal studies in a patient Z. W trakcie 3-letniej obserwacji nie stwierdzono nawrotu choroby. Przypadek 3 P. Podobnie jak w przypadku 1. Results of hormonal studies in a patient P. W trakcie 2-letniej obserwacji nie obserwowano cech nawrotu choroby.

Przemawia to za rozpoznaniem klinicznym guza kory nadnercza pomimo cech pheochromocytoma w badaniach histopatologicznych. Endocrinology and Metabolism Clinics of North America, 1 , 1— USA, 16 , — Cancer, 10 , — A study of a Brazilian population. Special considerations in children. Report of 2 cases and review of the literature.

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Endokrynologia Pediatryczna Pediatric Endocrinology

Przed i po 30 min. It seems, that catecholaminergic system plays an important role in stimulation of GH secretion. The aim of the study was to estimate the plasma adrenaline A and noradrenaline NA values and GH secretion during insulin and clonidine test in children with short stature. Materials and methods. The level of catecholamines A and NA was measured two-times by immunoenzymatic method: before and 30 min after insulin or clonidine administration. GH levels were during stimulatory tests concurrently evaluated.

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Endokrynologia pediatryczna

Most often it occurs shortly after the beginning of the therapy. A wide spectrum of clinical symptoms is observed. This complication is usually described in children with Turner syndrome, chronic renal failure and with considerable growth hormone deficiency due to multihormonal hipopituitarism. We describe a 12 years old boy with multihomonal Vol.

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